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Isotopia Company and Prof. Rachela Popovtzer of Bar-Ilan University are developing an innovative method for diagnosis and treatment of cancer

The Israeli Isotopia Company, in collaboration with Prof. Rachela Popovtzer of Bar-Ilan University, is conducting a joint study to develop a radioactive marker, based on nanoparticles, for the detection of cancer.   The goal of this research is to facilitate, for the first time, the distinction between tumors and inflammation.

The most common imaging method for diagnosing and monitoring cancer today is the positron emission tomography (PET) scan used with radioactive contrast material fluorodeoxyglucose (FDG). But FDG gives high rates of false positives, which lead to false therapeutic observations and expensive costs for health care systems. The main problem is that the test can detect not only tumors, but also inflammation, making it difficult to differentiate between cancerous growths and inflammation.

The material being developed by the researchers is a radioactive contrast agent based on nanoparticles.  In addition to identifying, imaging and tracking cancer tumors, these nanoparticles make it possible to make an unequivocal distinction between tumor and inflammation.

“The technology we are developing is significant because it will enable physicians to make a better diagnosis,” said Dr. Eli Shalom, CEO of Isotopia Molecular Imaging.  “Another advantage is that it will be used in existing PET/CT centers and rely on equipment that’s already in place,  so it’s very economical.”

Dr. Shalom said that the vision in this development is far beyond specific cancer identification.  “The method we are developing can be combined with Lu177  for therapy as well as the imaging.  This is an innovative field called Theranostics (therapy + diagnostics). In the Theranostics model, we use the same molecules and radiolabel them for imaging and therapy each time with a different isotope. “. Isotopia, which today focuses on the development of Theranostic products for prostate cancer, will be an excellent platform for bringing development to the Global market

The research is being carried out within the framework of the “Magneton” program of the “Innovation Authority” (formerly the “Bureau of the Scientist”), which funds research aimed at encouraging the transfer of technological know-how accumulated in academia for innovative industry products. Fundraising for Magneton (for Bar-Ilan University) was overseen by Birad Research and Development Company Ltd.”.

About Isotopia
Isotopia, the nuclear pharmacy with knowledge and experience in the radiochemical connection, has extensive experience in developing processes and applying them for molecular imaging. The Isotopia development team is a multidisciplinary team consisting of nuclear pharmacists, radiochemists, nuclear engineers and physicists.

The experienced Isotopia team, together with its radio-nuclear pharmacy and cyclotron facility, are a well-established platform for development. Isotopia conducts research and development initiatives in cooperation with leading medical centers and with leading research laboratories in Israel. Isotopia creates collaborations between the scientific and medical community to further develop and experiment with new markers for imaging applications and molecular therapy. Isotopia develops strategic partnerships in procurement, production and international sales of Isotopes in the manufacture of cyclotron, radio-pharmaceuticals and related molecular imaging technologies, as well as new developments in the field of radiotherapy.

About Birad – Research & Development Company Ltd. The commercializing company of Bar-Ilan University, which promotes collaborations, corporations and alliances to manage the intellectual property, and technology commercialization by creating risk and licensing, promoting scientific service agreements through the technological knowledge and infrastructure of the University for the benefit of members of the industrial community, and outsourcing services for the business sector as part of the Division of Scientific Services.

For more information: Merav Burstein. Tel: 0773643534. Merav@birad.biz

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CogniFiber has been selected to take part in Intel’s Ingenuity Partner Program (Intel IPP)

As part of the program, CogniFiber will be mentored by experts from Intel’s business organizations, will be exposed to state-of-the-art technology, along with an educational infrastructure and local and international events.

CogniFiber has been chosen to participate in the fourth cycle of Intel’s prestigious program for leveraging startups. The program’s framework is based on a demo and POC which is built on defining joint project goals for CogniFiber and Intel. The company will gain mentoring by experts from Intel’s business organizations, will be exposed to state-of-the-art technology, together with an educational infrastructure and local and international events.

Cognifiber is a leader in the field of photonic computing, the emerging technology of the next decades. The primary development of the technology on which the company was founded was done by Dr. Eyal Cohen, who performed a post-doctorate research in the laboratory of Prof. Zeev Zalevsky, from the Faculty of Engineering, in Bar-Ilan university in collaboration with Dr. Mickey London from The Interdisciplinary Center for Neural Computation (ICNC), The Hebrew University of Jerusalem, as an additional advisor. Dr. Eyal Cohen approached the two with a proposal to carry out the research and with Prof. Zalevsky’s extensive experience, promoted the research and its commercialization through BIRAD, Research & Development company Ltd. and the Deputy President of Bar-Ilan university.

Dr. Eyal Cohen together with Prof. Zalevsky and Ms. Keren Levy, who served as a business advisor for the company, co-founded the company. Dr. Eyal Cohen, acts as the leading entrepreneur and company CEO, Prof. Zeev Zalevsky is the company CTO and Keren Levy acts as the company COO.

CogniFiber implements advanced algorithms such as machine learning and deep learning neural networks within unique optic fibers, which enable up to 10,000x acceleration in computation rate, coupled with a staggering 10x-100x reduction in power consumption and heat dissipation, at these computation rates. CogniFiber’s photonic devices will not only revolutionize the world of AI and computing, but will also make AI cheaper, more mobile and more accessible. In-fiber photonic computing devices can deliver a solution for the ever-growing processing needs, they are easy to manufacture, scalable, fault-resistant, and could be connected to any existing communication platform.

Intel’s IPP program is open (every cycle) for about 10 companies and offers them 6-8-months of professional mentoring framework to improve their technology and products, while leveraging on Intel’s technological resources, global presence, and vast network of business connections, in preparation for a successful market penetration. The program is in collaboration with Intel Capital, one of the world’s biggest Venture Capitals, which enables entrepreneurs direct access to this track.

The IPP program, which began operating in 2015, has accompanied about 30 companies, which raised a total of 281 million dollars between them in the past three years. 93% of the companies are still active, and Intel does not demand or take equity or percentages.

With the purchase of Mobileye, Replay, and positioning Intel as a data company, Intel is without a doubt a central player in all emerging and exciting technologies of today’s industry and acts as an excellent source for entrepreneurs who want to accelerate their product or technology.

http://www.Intel.com/ipp

BIRAD:

Birad – Research & Development Company Ltd. the commercializing company of Bar-Ilan University, which promotes innovative technology commercialization, invented by university researchers, encourages scientists to promote their researches and expand them towards industrial and implementational initiatives.

Additional details at the company’s site: www.birad.biz

For additional info regarding CogniFiber: http://www.cognifiber.com

For additional details: Merav Burstein – 052-2229330 – merav@birad.biz

 

 

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Researchers Invent Nano-Drops That Improve Nearsightedness and Farsightedness

 

Nano-Drops May Offer New Alternative to Current Methods of Vision Correction

Ramat Gan, Israel — A revolutionary, cutting-edge technology, developed by researchers at Bar-Ilan University’s Institute of Nanotechnology and Advanced Materials (BINA), has the potential to provide a new alternative to eyeglasses, contact lenses, and laser correction for refractive errors.

The technology, known as Nano-Drops, was developed by Dr. David Smadja (Ophthalmologist from Shaare Zedek Medical Center), Prof. Zeev Zalevsky, from Bar-Ilan’s Kofkin Faculty of Engineering, and Prof. Jean-Paul Moshe Lellouche, Head of the Department of Chemistry at Bar-Ilan. A related patent on this new invention was recently filed by Birad – Research & Development Company Ltd., the commercializing company of Bar-Ilan University.  Steve Elbaz is a Co-Founder and Chief Business Officer of the new technology.
Nano-Drops achieve their optical effect and correction by locally modifying the corneal refractive index. The magnitude and nature of the optical correction is adjusted by an optical pattern that is stamped onto the superficial layer of the corneal epithelium with a laser source. The shape of the optical pattern can be adjusted for correction of myopia (nearsightedness), hyperopia (farsightedness) or presbyopia (loss of accommodation ability). The laser stamping onto the cornea takes a few milliseconds and enables the nanoparticles to enhance and ‘activate’ this optical pattern by locally changing the refractive index and ultimately modifying the trajectory of light passing through the cornea.

The laser stamping source does not relate to the commonly known ‘laser treatment for visual correction’ that ablates corneal tissue. It is rather a small laser device that can connect to a smartphone and stamp the optical pattern onto the corneal epithelium by placing numerous adjacent pulses in a very speedy and painless fashion.  Tiny corneal spots created by the laser allow synthetic and biocompatible nanoparticles to enter and locally modify the optical power of the eye at the desired correction.

In the future this technology may enable patients to have their vision corrected in the comfort of their own home. To accomplish this, they would open an application on their smartphone to measure their vision, connect the laser source device for stamping the optical pattern at the desired correction, and then apply the Nano-Drops to activate the pattern and provide the desired correction.

Upcoming in-vivo experiments in rabbits will allow the researchers to determine how long the effect of the Nano-Drops will last after the initial application. Meanwhile, this promising technology has been shown, through ex-vivo experiments, to efficiently correct nearly 3 diopters of both myopia and presbyopia in pig eyes.

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ContinUse Biometrics one of ten start-ups to take first place in 2018 Prism Awards for breakthrough applications in photonics

Company recognized for its development by Bar-Ilan University engineering professor of a biometric sensing system that detects biomedical parameters from a distance without human contact

Israeli start-up ContinUse Biometrics is among the ten first-place winners of the prestigious 2018 Prism Award (the Oscar of the photonics industry) for the Medical and Health category.  The company is being recognized for its invention of an optical sensing system (sensory camera) in a competition sponsored by Photonics and SPIE Media This is the tenth year that the competition has been held.

“We chose the ten companies that introduced the greatest innovation and creativity in their products and showed impressive data and performance in every possible parameter.  These are inventions that, without a doubt, advance the photonics industry and its prosperity,” noted the organizers of the competition.

ContinUse Biometrics took first place for its laser-based detector and camera that remotely and accurately identify nanoscale movements.  The sensor is aimed at the subject, enabling accurate physiological data to be obtained.

ContinUse Biometrics focuses on developing novel devices for the health field in general and preventive medicine in particular — for use in the home, the vehicle, the workplace and the clinic.  Its products enable ongoing monitoring of vital indicators and patients suffering from chronic diseases such as heart disease, respiratory diseases, and more.

The products developed by ContinUse Biometrics is ideal for senior citizens by virtue of the fact that it transfers medical care from the doctor’s office to the home environment and alerts medical professionals to any change in vital indicators.  The attending physician receives all the readings remotely and provides appropriate medical instructions to the patient. This Telemedicine platform has the potential to minimize visits to clinics and/or hospitalization, while monitoring the patient in his own home in a comfortable, non-contact environment and increased level of service.

The detector is based on the development of Bar-Ilan University engineering professor Zeev Zalevsky, Chief Technology Officer of ContinUse Biometrics. . The detector identifies several groups of physiological parameters including vital signs such as heartbeat,, breathing and blood pressure; allows for listening to heart and breathing sounds (much like a stethoscope); identifies changes in peripheral blood flow patterns; identifies hematologic parameters; identifies people according to their heart tone; and provides muscle and bone measurements including changes in muscle tone and detection of fractures. All measurements are conducted remotely, with no human contact.

The response of medical markets to this development has been most enthusiastic, and the business potential is estimated at hundreds of millions of dollars. In addition, the company plans to activate the sensor in clinics and operating rooms. In this framework, the company will perform several hospital clinical trials over the coming year.

ContinUse Biometrics was founded by CEO Asher Polani with assistance from Bar-Ilan University’s BIRAD Research and Development Company Ltd., which promotes the commercialization of innovative technologies invented by university researchers, and encourages scientists to advance and expand their research with an eye toward industrial applications.

For further information, contact: Merav Burstein, BIRAD Research and Development Company Ltd., 077-3643534, 052-2229330, Merav@birad.biz