Technologies On The Shelf

Diagnostic & Medical Devices
Energy, Environment & Clean-tech
Nanotechnology, Chemistry & Cosmetic
Pharmaceutical Indications & Biotechnology
Ultra-sensitive Sensors
Scientific Tool Kit
Semiconductors & Engineering
Diagnostic & Medical Devices

Glucose Conjugated Gold Nano-particles for Cancer Detection

The Problem:

Cancer detection is currently based on two insufficient imaging techniques: structural and functional. While structural techniques identify anatomic details and provide information on tumor location, size and spread, based on endogenous contrast, they are ineffective in detecting critical small tumors or metastases. The main functional imaging technique, FDG-PET, is based on increased glucose metabolic activity in cancerous tissue However, it is prone to non-specificity as glucose uptake is not cancer-specific, it is dependent on availability of short-lived cyclotron radio-tracers, and above all, it lacks anatomical information of the functional results.

The Solution:

We have developed a novel method that will provide simultaneous functional and structural imaging capabilities, with the most widely available imaging modality – the CT. We have developed Glucose Functionalized Gold Nanoparticles (GF-GNP), which like FDG, detects glucose metabolic activity while inducing distinct contrast in CT imaging. We have discovered that these GF-GNP exhibit increased uptake in cancer cells compared to the surrounding normal tissue.

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Metabolic Imaging Of Cancer Using CT

The Problem:

Current conventional structural diagnostic modalities do not detect evident of cancer lesions at early stages as they are not cancer-specific.

The Solution:

The functional imaging FDG-PET provides the ability to visualize cancer cells based on their increased glucose metabolic activity and can detect tumor presence at early stages that conventional structural diagnostic modalities do not yet detect any evident lesions.

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Novel Magnetic Gel Platform for Transplantation

The Problem:

Mimicking the nature composition and structure of tissues is a considerable challenge in medicine. Currently this can be partially achieved with prefabricated implants.

The Solution:

Prof. Shefi’s team invented a novel approach of injectable biomaterials, to be incorporated directly into the injured site.

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Machine Learning Based Diagnostics of Heart Failure

The Problem:

Current practice requires manual extraction of heart failure parameters.

The Solution:

Our cutting-edge Machine Learning (ML) algorithms can automatically extract different parameters from a patient's echo-cardiograms.

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An Interactive Gaze Contingent System for the Diagnosis and Treatment of Social Communication and Attention Deficits in Infants and Children

The Problem:

Over the last two decades a dramatic increase in the prevalence of socio-communicative disorders and attention disorders was reported. Today 1 of every 68 children is diagnosed with ASD and 1 of every 10 children is diagnosed with ADHD/ADD. There are four major problems that limit effective diagnosis and treatment: 1) Diagnosis is typically enabled too late: The earliest age for diagnosis is at least 2-3 years of age with a mean that is close to 4 years. This age is too late for making a major change in brain organization. The brain is most plastic during the first 3 years of life. 2) Diagnosis and care rely on subjective measures: Currently, behavioral markers typically noted for diagnosis rely on subjective non-quantifiable measures of gaze orienting, attention and exploration, preference of non-social stimuli over social stimuli (faces) and atypical and reduced eye contact 3) Currently, once diagnosed (at 3 or 4 years of age) intervention with a therapist is highly costly, unavailable to most and is given at too low rates 4) Currently, clinical interventions are administered in clinical settings. This limits accessibility for young infants, and precludes intensive care to enable the needed change.

The Solution:

An early diagnosis and individually-tailored intervention may have a disproportionately large impact in the first two years of life when most brain connectivity is created. This will lead to a more promising long term functional outcome.

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Improved Tumor Margins Detection Using Gold Nano-rods

The Problem:

Most optical-physiological diagnoses are based on the insertion of light, with known parameters, to a tested tissue, followed by the measurement of the reflected, transmitted or absorbed light. Changes in the optical properties of this light such as its spectrum, polarization or intensity, compared to the injected light, result from interactions of the irradiated light with the tissue's components. Current methods are not only as sensitive as required but also are invasive causing pain to patients.

The Solution:

Our cutting-edge method for cancer detection is based on Diffusion Reflectance (DR) measurements of gold nano-rods (GNR).

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Novel 64cu(Ii) Radiotracer  For Diagnostic Of Hypoxia

The Problem:

The development of a biomarker for hypoxic tissues is essential both for diagnostic formulation and treatment planning for most cancer patients.
Although the current PET radiotracers are non-invasive imaging modality techniques of tumor hypoxia, they are not being used routinely due to slow uptake by hypoxic.
Cu(II)-tracers have been suggested to become one of the most promising PET agents for hypoxia imaging. However, one of the main drawback of Cu(II)-ATSM compounds is that they
can also dissociate Cu(II) in normal and hypoxia cell, causing to chelation of Cu(II) by SOD and cytochrome C, and other rich proteins causing to:
• Unwanted cellular reactions resulting in toxicity
• Low signal to background ratio of the radiotracer
• Specificity problems

  The Solution:

   We present a novel 64Cu(II) based radiotracer that is incorporated in the copper cycle

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Energy, Environment & Clean-tech

Leading, Innovative Anti-Microbial Coating

The Problem:

The presence of microbial contamination of surfaces poses a serious problem from the point of view of health protection. There is a growing market demand to improve effectivity, safety, endurance and cost of anti-microbial coating.

The Solution:

We propose a novel bio-inspired nanocapsule that can firmly attach to any surface and kill encapsulated bacteria.

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Novel, Low-cost Method for Fabricating Multi-metallic Hydrogen Oxidation Electrocatalyst Materials

The Problem:

In polymer electrolyte membrane fuel cells, the electro-catalysts, membrane and metal hardware are expensive. So far, the electro-catalysts failed to reach a cost-effective level

The Solution:

The invention relates to the preparation of multi-metallic electro-catalysts. These electro-catalysts display higher activities than those synthesized by current methods.

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Economic, Useful Anode Catalyst for Use in a Redox Flow Battery

The Problem:

Current energy storage system batteries for stationary substation applications are extremely expensive.

The Solution:

This innovation provides an anode catalyst having superior stability in a highly corrosive environment when operated in redox flow battery systems, while still exhibiting improved performance, and that is durable and cost-effective.

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A Bimetallic Catalyst and Fuel for Use in a Direct Dimethyl Ether Fuel Cell

The Problem:

At the current rate of global energy demands, new, alternative energy technologies must be developed to accommodate our needs. For more than a decade, it was strongly believed that hydrogen can help address the growing demand for energy and slow down global climate change. Hydrogen fuel is used together with oxygen in an electrochemical cell, which converts their chemical energy into electricity. This technology is called fuel cell. While hydrogen conversion is already technologically feasible, its delivery and storage face serious challenges. The cost of hydrogen storage and delivery is too high for many energy applications, thus impeding the introduction of the hydrogen as a major energy carrier.

The Solution:

Our forefront solution replaces the use of hydrogen with Dimethyl Ether (DME). DME can be liquefied under low pressure and produce relatively high energy density. DME-based fuel cells may become one of the most promising alternative energy technologies due its high energy density, low cost and physical properties which make it very easy to handle.

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Novel Multi-Application Disinfection Technology

The Problem:

Microbial infections represent one of the leading causes of death worldwide. Users of antiseptics and disinfectants are individual consumers as well as various groups and industries such as research institutions, food handlers, textile manufacturers and healthcare providers. Antiseptics and disinfectants are a vital set of compounds for healthy living.

The Solution:

A portable, cheap and re-usable method of generating and applying electrolyzed water (EW) that enables more widespread use of this alternative disinfecting and cleaning agent.

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Nanoparticles for Re-chargeable Eco Friendly Self-cleaning of Industrial and Medical Surfaces

The Problem:

Bacterial attachment to surfaces leading to the formation of communities of bacterial cells is a major problem as bacteria's most characteristic phenotype of the biofilm mode of growth is its inherent resistance to disinfection, antimicrobial treatment and immune response killing.

The Solution:

This novel invention provides environmental-friendly polymeric nanoparticles exhibiting antimicrobial and self-cleaning activity following a simple halogenation procedure.

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Efficient and Economic Selective Bromide Ions Removal and Recovery of Water

The Problem:

Development of bromine compounds markets is strongly affected by new global environmental regulations that forbids the production of waste water containing bromide that are discharged to surface water systems. Furthermore, high bromide in conjunction with high organic carbon (OC) is widely recognized to be the worst-case scenario for drinking water plants. Inability to achieve low bromide concentrations by existing technological processes of water treatments will lead to annual addition of at least ~$200 million. Also, forbiddance of use brominated flame retardants and biocides, hydraulic fracking ban will lead to loss of hundred million dollars every year.

The Solution:

We developed simple, effective and cost-effective technology for specific removal and recovery of bromide ions from water. This cutting-edge technology removes and recovers bromide ions by electro-oxidation in the Asymmetric CDI (A-CDI) cells.

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Nanotechnology, Chemistry & Cosmetic

A Novel Encapsulated Stabilized Vitamin A (Retinoic Acid) for Cosmetic Applications

The Problem:

All-trans retinoic acid, the most active form of vitamin A, is known to be highly beneficial in dermatology and other biomedical applications. However, all-trans retinoic acid is extremely sensitive when exposed to ultraviolet (UV) light, due to the conjugated double bonds that comprise its chemical structure.

The Solution:

Our cutting-edge invention is a nano/micron-sized retinoic acid-filled hollow proteinoid particle composed of polymerized para-amino benzoic acid (a UV blocker) and polymerized amino acids. This non-toxic biodegradable particle may contains up to 20% trans-retinoic acid, protecting it from light-degradation for over 24h, while free RA degrades within only 3h of light exposure under same conditions.

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Innovative System & Technique for Correction of Eye Conditions

The Problem:

A vast majority of people suffer from serious visual problems such as myopia, hyperopia or presbyopia. The aging global population and increasing prevalence of chronic diseases resulting from unhealthy lifestyle will continue to drive growth in therapeutic eye care services. Existing treatments include the use of spectacles, contact lenses, and laser surgery.

The Solution:

This proposed novel treatment might be executed on everyone, making spectacles or contact lenses redundant. This innovative therapy includes the use of a portable laser towards specific laser patterns onto the patient cornea (upper layer burning) followed by pattern stabilization/functionalization with fully bio-compatible nano-particles (NPs, NPs-based eye droplets) that strongly and positively modify patient eyes refractive indexes with highly positive therapeutic consequences.

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Innovative Therapeutic DNA Nano-Robots

The Problem:

Contemporary cancer therapies involving invasive surgery and blasts of drugs can be as painful and damaging to the body as the disease itself.

The Solution:

Our DNA nano-robots could potentially change the world of medicine as we know it. We are using DNA as a programmable building block for the design and fabrication of logic-guided nano-robots and machines. These machines can be programmed to carry out autonomous tasks based on biological computing. We are also using them as chassis to fabricate multi-agent systems with biometric swarm behaviors and decentralized logic. Our DNA nano-robots could potentially change the world of medicine as we know it. They can be utilized as an internal disease management system, combining specific delivery of one or more molecules with conditioned (programmed) response to environmental signals (internal and external).

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Prevention and Treatment of Viral Infections with Nano-particles Capped with Functional Groups

The Problem:

Viral infections continuously take place and pose major public health treats; yet, their prevention and treatment modalities are limited while emerging resistant viruses call for the development of alternative treatments.

The Solution:

We developed a novel approach for the prevention and treatment of infections caused by viruses which attach cells via heparan sulfate binding, such as the herpes simplex virus type 1 (HSV-1), HSV-2 and human immunodeficiency virus (HIV).

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Novel 3d Photo-thermal Printing of Metals & Composites

The Problem:

While 3D printing of polymeric materials is prevalent, metals are indispensable for structural support, heat dissipation and electrical conductivity. Extensive research to allow additive manufacturing (AM) of metals has resulted in a range of techniques, the most established of them are selective laser melting (SLM), electron beam melting (EBM) and metal inkjet printing. Alas, these methods are not suitable for the microscale regime due to minimum line width of tens of microns, limited by the size of metal particles used and heat dissipation.

The Solution:

Our new technology, based on photo-thermal reduction of metal ions, is breaking new ground in several aspects:

  • Very fine (~1µm feature size) single metal OR multiple metals structures.
  • Very good and homogenous structure with very fine surface roughness due to the built-in sintering process.
  • Ability to combine nano-diamonds, nano-carbon particles and such (composite formation) for better finished material properties (either electric, magnetic, heat transfer etc.)

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Novel 2d Monolayers of P-Type Copper Sulfide

The Problem:

Current methods does not allow for an industrially feasible production of 2D-layered bulk copper sulfide. Such material can be used asis or be exfoliated into monolayers to exhibit significant, advantageous commercial characteristics for specific technological applications.

The Solution:

Our cutting-edge invention provides a simple and scalable method for the synthesis of single stoichiometry 2D layered bulk copper sulfide, which does not require nor produce toxic compounds.

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Pharmaceutical Indications & Biotechnology

Novel Peptides for Treating Cocaine Addiction And Pain

The Problem:

  1. Drug addiction is a scourge of both developed and less-developed societies. The economic impact of drug addiction includes direct treatment costs as well as lost productivity and crime.
  2.  Neuropathic pain is a chronic pain condition caused by a primary lesion or dysfunction in the nervous system. It can be a consequence of many different insults, such as trauma, neuronal injury, infection or addiction to narcotics. Neuropathic pain has a significant adverse impact on life, health and functions and is difficult to treat.

The Solution:

Bar-Ilan and Ariel University teams have identified novel peptides for treating addiction and possibly pain. The peptides were shown to be specific agonists to the delta opioid receptor (δR), which is directly involved in drug craving and pain. We bond the peptides to PEPnanoparticles which assist their passage across the blood-Brain-Barrier (BBB) after intranasal administration.

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Novel Drug for Glaucoma Treatment

The Problem:

Glaucoma is one of the leading causes of blindness in the world. It is a slow and progressive disease that can lead to vision loss over a long period of time. Over 60 million people worldwide lives with glaucoma using multiple therapies in order to prevent blindness- and the patients' number will grow as population aged. The exclusive focus of glaucoma treatment continues to be on control of intraocular pressure (IOP) though this approach is not sufficient in all patients, leading them to blindness.

The Solution:

Bar-Ilan University is developing a novel patented drug candidate, A1-46, for the treatment of diseases modulated by the pyrimidinergic receptor P2Y6. A1-46, nucleotide derivative screened and selected from the proprietary nucleotides library from Prof. Fisher lab, structurally designed as 5-OMe-UDP (α-B), was evaluated as a potent and highly selective P2Y6-receptor agonist.  

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Novel Personalized Amd and Diabetic Retinopathy Treatment

The Problem:

Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures. Current treatment for AMD and DR includes monthly intraocular injection of various anti-VEGF agents. Novel biological drug family based on nucleic acid-based ligands, aptamers, is proven for use in ophthalmology. Although these new treatments are promising, they have severe limitations. Not only they involved complicated surgical procedure, but also they are performed without direct measurement of disease bio-markers in different patients. Therefore, there is still a high demand for more personalized and safer approach to improve efficiency and compliancy.

The Solution:

Our innovative technology directed to non-invasive methods of personalized diagnosis and treatment of ocular disease, Age Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) using novel nano-particle-mediated delivery of aptamers based on personalized medicine approach.

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Innovative Anti-Microbial and Anti-Biofilm Therapeutics Against Multidrug Pseudomonas Aeruginosa

The Problem:

Antibiotics are arguably the most successful form of chemotherapy developed in the twentieth century and perhaps over the entire history of medicine. However, antibiotic resistant bacteria are emerging and spreading world-wide and too often antibiotics are taken for granted. The U.S. Centers for Disease Control and Prevention and World Health Organization defines antibiotic resistance as one of the world’s most pressing public health problems, and estimates that millions of people die each year from infections due to bacteria that are resistant to treatment by one or more drugs. In the last two decades, due to the continuous consumption of antibiotics, injudicious use of existing drugs, and the on-going evolution and spread of resistance genetic elements, multidrug resistant (MDR) and even extremely drug resistant (XDR) bacteria have emerged. These bacteria exhibit resistance to multiple antibiotics and sometimes to nearly all commercially-available antibiotics, and cause increased patient morbidity, mortality and costs. In this group is MDR Pseudomonas aeruginosa, a notorious pathogen that causes a wide range of hard to treat nosocomial infections.

The Solution:

Our notable innovation presents novel treatments against multi-drug resistant Pseudomonas aeruginosa infection and disease.

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Targeting Amyloid Diseases with Self-assembled Cyclic D,L-α-Peptides

The Problem:

Protein misfolding and aggregation is the fundamental cause of more than 20 amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. These conditions include Alzheimer’s, Parkinson’s, and Huntington’s diseases, and type II diabetes. For Alzheimer’s disease (AD), the oligomerization of amyloid beta (Aβ) and tau to soluble oligomers and their accumulation in the brain are believed to be the primary pathogenic events that lead to neuronal cell death, while aggregation of α-synuclein (α-syn), amylin, huntingtin, and superoxide dismutase are responsible for the etiology of Parkinson’s disease (PD), Huntington disease (HD) and amyotrophic lateral sclerosis (ALS), respectively. However, misfolded proteins do not fully retain their native biological activity and they exist under a dynamic equilibrium between monomeric and oligomeric forms. It is now accepted that soluble aggregates of different amyloidogenic proteins, which are rich in -sheet conformations, are the most toxic species.

The Solution:

Our novel discovery is that CP-2 target the formation of toxic oligomers and changes their aggregation process to generate “off pathway“ intermediates, most probably due to its immense structural and functional similarities to the amyloids.

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Effective Nanoscale Targeted Anti-leishmania Drug and Technological Platform for Nano-medicine

The Problem:

Leishmaniasis is a vector-borne tropical disease that affects 88 countries worldwide. The causal agent is a parasitic protozoon, Leishmania ssp. Cutaneous leishmaniasis (CL), caused by L. major, L. mexicana, and visceral leishmaniasis caused by L. donovani, is one of the most important neglected tropical diseases. Available treatments are highly toxic, and the serious side effects require close monitoring of the patients. Additional limiting factor to use current drugs effectively is a fast parasite-developed resistance to these drugs has been reported. Moreover, iv administration reduces opportunity to be used in developed countries in routine without hospitalization. Therefore, there is a need for additional therapies for treating Leishmaniasis.

The Solution:

Our cutting-edge, i.e., a nanoparticulate drug-like nanomaterial, Nano Lesh IL NPs, efficiently kill parasites within a few minutes of exposure locally. The NPs mechanism of action (MoA) was studied in vitro, ex vivo on parasitic cultures and in mice model. The novel MoA interferes with an essential parasite cell biology for host-parasite survival and results in lysosomal targeted damage. The LEISH IL NPS eliminate the visceral infection in mice after 2-3 injections of the drug. Topical formulation is in progress and preclinical test and clinical trials for cutaneous leishmaniasis will start soon.

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Novel Therapeutic Antibodies for Robo Receptors

The Problem:

De-regulation of Robo receptors appear in a number of diseases and types of cancer and the therapeutic potential for drugs that will modulate Robo activities is therefore high, but no such drugs exist.

The Solution:

Novel structure-based design of agonistic and antagonistic antibodies for Robo receptors.

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Ultra-sensitive Sensors

Ultra-sensitive, Miniature, Low Power, Inexpensive Magnetometer

The Problem:

Currently available inexpensive and miniature commercial magnetic sensors exhibit field resolution of hundreds of picotesla and above, while commercial sensors with field resolution of few picotesla and below are normally much larger and more expensive and in some cases operate only at cryogenic temperatures. Namely, there are no commercial magnetic sensors which are miniature and inexpensive and still exhibit field resolution of few picotesla.

The Solution:

Innovative magnetic sensors which are based on the Planar Hall Effect (PHE).

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“Xsense” - Extra-sensory Enhancement of Vestibular Signals for the Elderly

The Problem:

Age-related vestibular loss puts older people at a significantly higher risk of falling - the leading cause of hospital admission and accidental death in the elderly. Older adults with a history of dizziness and imbalance are at a higher risk of falling. So far, there is not a proper solution to improve deterioration of vestibular function.

The Solution:

Our biologically inspired sensory substitution algorithm and device augments/replaces lost vestibular signals. Providing these signals to the elderly will improve their sense of balance and orientation, and thereby reduce the incidence of falls, and improve their state of well-being.

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Scientific Tool Kit

Novel Delivery Vehicle for Cell Transfection

The Problem:

Nanoparticles can be manufactured with tunable size, shape and surface as well as biological activity. Their role as nanocarriers is well established. While many nanoparticles are stable as an aqueous colloid, ferro fluid, they maintain an insufficient active surface and are limited in their capacity for further modification or surface engineering.

The Solution:

In this cutting-edge technology a stable nanoparticle has been designed. It is composed of a metal oxide (maghemite, Fe2O3) core particulate system and a shell made of cerium (III/IV) cations and complexes.

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A Gene Gun for Electrical Delivery

The Problem:

Presently the most widely employed micro projectile gun methods involves the use of gas-driven acceleration to launch high velocity DNA coated gold or titanium micro particles which puncture and penetrate cells.

The Solution:

Our innovative, very promising gene gun technology can be made more accessible by eliminating the need for an external gas source and incorporating the use of less costly delivery agents. In a nutshell, our cutting-edge invention is less expensive and more useful

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Advanced Microscopic Methods to Measure Dynamic Patterns of Intracellular and Intranuclear Proteins in Living Mammalian Cells

The Problem:

The appropriate functioning of living cells depends on a variety of dynamic processes that necessitate delicate motion, transportation, association, and disassociation in time and space. For proteins, it is important to know:

  1. Is there a mobile fraction and a fixed (bound) fraction?
  2. What is the ratio between these two sub-populations?
  3. What is the concentration of each one
  4. Other relevant factors such as the number of binding sites.

In addition, both for proteins and other structures (such as DNA loci), it is important to know different dynamic patterns such as the type of their dynamics – is it a directed motion, is it normal diffusion or restricted diffusion. It is important to know the length scale of the dynamics, the diffusion coefficients and more. These parameters serves as a tool for exploring biochemical processes. Although there are methods such as fluorescent recovery after photobleaching (FRAP) and fluorescence correlation spectroscopy (FCS), these methods can only give partial information from the list given above.

The Solution:

We developed a method that combines intensity measurement with time-resolved measurement. It uses a confocal microscope setup and require labelling a tested protein (or structure) with a fluorescent dye (such as GFP) in live cells. Then, the sample (live cells) is placed under the microscope and using the confocal setup, the intensity is measured at a given point in the sample, normally for about 20-60 seconds. During the measurement, the life time of the emitted photons are also measured. Then, the data is processed by combining few different methods. It gives many answers related to “the problem” described above. This includes

  1. The ratio of bound and free sub-populations of the protein.
  2. The diffusion coefficient of the mobile fraction.
  3. The concentration of the mobile fraction and the bound fraction.
  4. The parameters are confirmed by two different methods, both from the fluorescence intensity as well as from the fluorescence lifetime.

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Large Scale Detection and Quantification of Post Translational Protein Modifications

The Problem:

The amount of biological material and reagents available for PTM analysis is usually very limited. This is even more pronounced for membrane proteins. In contrast, the amount required for analysis PTM is significant. This discrepancy makes PTM analysis very difficult.

The Solution:

The minute amounts of biological material and reagents required for analysis using IMPA override the inherent limitation of PTM research imposed by MS, enabling application to low-mass tissues with relevance to basic and translational science

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Semiconductors & Engineering

Coordinated Silencing for Alien Mitigation in a Multi-carrier Transmission Scheme

The Problem:

Digital Subscriber Line (DSL) provides high-bandwidth data transmission and reception to customer premises over copper twisted-pair telephone wires. Because the wires are unshielded, they are vulnerable to various types of interference, including crosstalk both from other subscribers to the same DSL service and other entities outside the DSL system. Such crosstalk, referred to as “alien noise", can cause substantial degradation of the DSL signal/noise ratio (SNR) and capacity.

The Solution:

Embodiments of this invention take advantage of the multi-carrier modulation scheme and signaling protocols on DSL links to achieve better suppression of alien noise. This coordinated silencing allows the DSLAM to mitigate the alien signal and achieve higher overall throughput.

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Innovative Ultra-Miniature Ring Oscillator Temperature Sensor

The Problem:

An important power management functions in commercial IC’s is temperature sensing. Since commercial processors can have as many as 40 sensors, the industry is constantly pursuing a small, low power sensor.

The Solution:

We present a promising, novel ultra-miniature ring-oscillator sensor which at 750 um2 is the world’s smallest integrated smart sensor and has the one of the lowest energy consumption's.

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Highly Reliable SRAM PUF

The Problem:

The huge amount of sensing devices found in future cars, homes, workplaces and cities require a much stricter security requirement for identification and authentication. However, when the variation is small, the logical value will be determined by noise, and can vary from run to run and the bit is unstable. The unstable bits can be masked by fusing or in the trusted environment and the algorithm can be implemented with the stable bits and error correction codes. However, the error correction code exposes some information to the outside world and is thus less secure.

The Solution:

This cutting-edge technique improves the reliability of the SRAM PUF (Physical Uncloneable Function), by locating and disqualifying unreliable cells (using a method which we call Tilting). SRAM (Static random access memory).

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Cutting-edge, Physical Unclonable Functions Related to Inverter Trip Point

The Problem:

The huge amount of sensing devices found in future cars, homes, workplaces and cities require a much stricter security requirement for identification and authentication. It is essential that during hardware communication, the two parties are capable of identifying each other through secret keys and reliable authentication protocols. A technique which has recently emerged is the utilization of inherent semiconductor device mismatch to facilitate physical unclonable functions (PUFs). These PUFs are used to generate digital identifiers, unique to every chip, which are not even visible to the chip manufacturer. The quality of the security depends on the inherent uniqueness and reliability/controllability of these functions. The PUF relies on intrinsic undetectable manufacturing variations in the CMOS (complementary metal-oxide semiconductor) process. However, if their variation is small, the logical value will be determined by noise, and can vary from run to run. In this case the bit is unstable and the PUF value from this bit is unreliable.

The Solution:

We present a unique, cutting-edge technique that makes the inverter trip point PUF more reliable.

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Ultra-Low Power, Nw Level Bandgap Voltage Reference (Bgref)

The Problem:

With advances in Internet of Thing (IoT) applications and the expansion of mobile devices, energy consumption has become a primary focus of attention in integrated circuits design. These mobile battery operated devices need to operate for extended periods without recharging and therefore requiring ultra-low energy consumption. Many IoT devices require operation in a wide range of frequencies that are dynamically defined by the application. Low voltage operation in the "near-threshold" region has been shown to be the ideal way to dramatically reduce energy dissipation, still achieving reasonable performance. However, an aggressive scaling of supply voltage results in performance degradation and a much higher sensitivity to process variations and temperature fluctuations. In addition to the reduction in supply voltage, many of the circuits are duty cycled, and turned off during sleep states to save power. Some circuits are required to be “always-on” and as such their low power capability is crucial. The Bandgap reference is such a circuit.

The Solution:

We present a novel BGREF circuit which can operate as low as 2nW. This power is several orders of magnitude lower than the prior-art. It is also much smaller than most bandgap references, with an area of roughly 6000 um2. It also has a fast-wakeup mode, where it can operate at high power during wakeup, and then resume lower power operation.

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Cutting-Edge Complementary Dual Modular Redundancy Memory Cell 

The Problem:

With advances in Internet of Thing (IoT) applications and the expansion of mobile devices, energy consumption has become a primary focus of attention in integrated circuits design. These mobile battery operated devices need to operate for extended periods without recharging and therefore requiring ultra-low energy consumption. Many IoT devices require operation in a wide range of frequencies that are dynamically defined by the application. Low voltage operation in the "near-threshold" region has been shown to be the ideal way to dramatically reduce energy dissipation, still achieving reasonable performance. However, an aggressive scaling of supply voltage results in performance degradation and a much higher sensitivity to process variations and temperature fluctuations. In addition to the reduction in supply voltage, many of the circuits are duty cycled, and turned off during sleep states to save power. Some circuits are required to be “always-on” and as such their low power capability is crucial. The Bandgap reference is such a circuit.

The Solution:

We present a novel BGREF circuit which can operate as low as 2nW. This power is several orders of magnitude lower than the prior-art. It is also much smaller than most bandgap references, with an area of roughly 6000 um2. It also has a fast-wakeup mode, where it can operate at high power during wakeup, and then resume lower power operation.

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Gain Cell Embedded Dram In Fully Depleted Silicon-On-Insulator Technology

The Problem:

As technology dimensions continue to scale down, high density embedded memories are of great interest for many VLSI systems. However, 6T SRAM cells incur a large area penalty and suffer from high static power consumption in scaled CMOS nodes, often dominating the total area and power budget of a system. Gain-Cell embedded DRAM (GC-eDRAM) is an alternative to SRAM, featuring high density, non-destructive readout, low leakage, and two-port operation. However, GC-eDRAM:
• Requires refresh cycles to maintain data, with the refresh operation becoming the main power consumer in deeply scaled technology nodes.
• Suffers from high access latency compared to SRAM due to degraded levels in the cell. 

Hence, large design guard bands and performance margins are needed to ensure reliable operation under process variability.

The Solution:

We propose a novel GC-eDRAM implementation in FD-SOI technology, which significantly improves the data retention time and access latency using body biasing.

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Novel High-Density Memory Macro

The Problem:

Due to the growing demand for high-density embedded memories in modern microprocessors and other VLSI Systemon- Chip (SoC) designs, gain cell embedded DRAM (GCeDRAM) has emerged as an alternative to static random access memory (SRAM).  GCeDRAM is known for its high-density, non-destructive read operation, low leakage power,and two-port operation. However, GCeDRAM requires periodic refresh cycles to reliable retain data, both reducing the memory availability and consuming dynamic refresh power. While GC-eDRAM Implementations in mature technology nodes, such as 90 nm and 65 nm, provides long data retention time (DRTs), sub nm technologies suffer from much shorter DRTs due to the reduced parasitic storage capacitances and increased leakage currents.

The Solution:

We propose a novel memory macro suitable for deeply scaled CMOS technologies and high-bandwidth applications.

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Novel Transistor Gain Cell With Feedback

The Problem:

Embedded memories, typically implemented with a 6T SRAM bitcell consume an ever growing share of the total silicon area and power. Gain cell embedded DRAM (GC-eDRAM) is
an alternative to 6T SRAM, offering higher density, lower leakage, and 2-port operation. However, gain cells:
• Rely on dynamic storage,
• Results in very low data retention times
• Increases the power consumption
• Reduces memory availability

The Solution:

We propose a novel memory macro suitable for deeply scaled CMOS technologies and high-bandwidth applications.

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Silicon Photonics STED Plasma Dispersion Effect Super-Resolved Imaging in Silico

The Problem:

The silicon industry is currently heading toward 10 nm technology in integrated circuits. Promoting this market trend is largely dependent on the development of super-resolution
in silicon microscopy.

The Solution:

We propose a novel method that provides the ability to probe the silicon under surface in super-resolution. More specifically, we developed a new concept for beam shaping of an IR probe laser beam in the silicon by a second pump laser beam in the visible, absorbed in the silicon. The pump beam creates photo-charges that block the IR beam according to the lateral shape of the pump beam via the plasma dispersion effect. The pump beam could be either in a sharp Gaussian shape that induce a hole in the center of IR probe beam or the
pump beam is in a donut shape that blocked the IR beam while living a sharpen beam in its center.

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Licensing

BIRAD grants exclusive and non-exclusive licenses for the commercialization of BIU-based research findings, both to established companies and to new startup ventures established around University technology.

The licenses are granted for specific patents and/or know-how and are limited to a specific field and/or specific products. Licenses include diligence milestones for the development and sale of products covered by the license – to avoid technology "shelving" – and typically include a combination of the following forms of consideration: royalties, milestone payments, upfront fees, equity and/or annual license fees.

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Birad's team is ready to assist you :   

 

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Dr. Frances Shalit

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Nati Fisher

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Dr. Iris Haas

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Dr. Assaf Sagiv